This blog by Derek Nelson shows how he built an OpenSolver model for fantasy football that worked well for him. “My optimizer was created using Excel with the Open Solver add-in. This worked for me and the results were good. Namely, I had the highest projected points for my teams at the start of the season in both leagues I played in (the best you can hope for in the draft, in my opinion), and I ended the season by winning one league and placing second in the other.”
Derek has now gone on to create a cloud-based version of this. This work is an interesting optimisation-based project.